definintely NOT photoshop, you would want illustrator instead. Photoshop is for photographs, illustrator is for layouts and design.
quark would be the best program to use, but its more difficult to learn and perform basic tasks. Publisher would be the easiest to use, but for me it would not be professional enough. Illustrator is right in the middle and probably your best choice unless you have absolutely no idea what you are doing at all. and if thats the case i dont know why you would even have to make a brochure in the first place.