i don\'t think lost is really \'what happened, happened\'. and i think fringe is hinting at what it will be closer to.
that said, i believe that in this universe, things are predetermined. in this reality, you are doing this set of things. however, with the advent and continual reinforcement of membrane theory, i believe that at this moment in time, we are all doing an infinite amount of differing things in various parallel universes.
for example, in this universe i chose to wear a blue shirt today. in another, perhaps it was red. in another, perhaps it was also blue, but a different shirt. but all of these decisions were made at the same time.
i also tend to think that certain dreams are actually a look into your other realities.